Xing Dai, Ph. D.
D234 Med Sci I, Department of Biological Chemistry
School of Medicine, University of California
Irvine, CA 92697-1700
Tel: 949-824-3101
Fax: 949-824-2688
E-mail: xdai@uci.edu

EDUCATION:

1995 Ph. D. in Biochemistry and Molecular Biology
University of Chicago, Chicago, Illinois
1989 M. S. in Biochemistry and Biophysics
University of Hawaii at Monoa, Honolulu, Hawaii
1985 B. S. in Biology
East China Normal University, Shanghai, P. R. of China

EMPLOYMENT:

1987-1989 Research Assistant, University of Hawaii, Honolulu, HI, Department of Biochemistry and Biophysics
1989-1990 Teaching Assistant, University of Chicago, IL, Dept. of Biochemistry and Molecular Biology

1989-1992

Research Assistant, University of Chicago, IL, Dept. of Molecular Genetics and Cell Biology

1992-1995

NIH pre-doctoral trainee, University of Chicago, IL, Dept. of Biochemistry and Molecular Biology

1995-1999

Postdoctoral Fellow, University of Chicago, IL, Dept. of Molecular Genetics and Cell Biology, Howard Hughes Medical Institute

1999-Present

Assistant Professor, University of California, Irvine, Dept. of Biological Chemistry

HONORS AND AWARDS:

1992 NIH Biotechnology Pre-doctoral Training Grant Award

1995

Departmental award for outstanding performance in the field of Biochemistry and Molecular Biology at the University of Chicago (generally known as the “best thesis award”)
1995 Howard Hughes Medical Institute Postdoctoral Fellowship
1996 NIH Individual National Research Service Award

PUBLICATIONS:

Ogata, K., Dai, X., and Volini, M. (1989). " Bovine mitochondrial rhodanese is a phosphoprotein". J. Biol. Chem. 264, 2718-2725.

Glucksmann-Kuis, M. A., Dai, X., Markiewicz, P., and Rothman-Denes, L. B. (1996). "E. coli SSB activation of N4 virion RNA polymerase: specific activation of an essential DNA hairpin required for promoter recognition".  Cell 84, 147-154.

Miller, A., Dai, X., Choi, M., Glucksmann-Kuis, M. A., and Rothman-Denes, L. B. (1996). "Role of single-stranded DNA binding proteins in transcriptional activation".  Methods in Enzymology 274, 9-20.

Dai, X., Greizerstein, M., Nadas-Chinni, K., and Rothman-Denes, L. B. (1997). "Supercoil-induced extrusion of a regulatory DNA hairpin".  Proc. Natl. Acad. Sci. USA 94, 2174-2179.

Dai, X. and Rothman-Denes, L. B. (1998). "Sequence and DNA strucutral determinants of N4 virion RNA polymerase-promoter recognition".  Genes & Development 12, 2782-2790.

Rothman-Denes, L. B., Dai, X., Davydova, E., Carter, R., Kazmierczak, K. (1998). "Transcriptional regulation by DNA structural transtions and single-stranded DNA binding proteins". Cold Spring Harbor Symposium on Quantitative Biology LXIII, 63-73.

Dai, X., Schonbaum, C., Degenstein, L., Bai, W., Mahowald, A., Fuchs, E. (1998). "The ovo gene required for cutcle formation and oogenesis in flies is involved in hair formation and spermatogenesis in mice". Genes & Development 12, 3452-3463.

Dai, X., Kloster, M., and Rothman-Denes, L. B. (1998). "Sequence-dependent extrusion of a small DNA hairpin at the N4 virion RNA polymerase promotes".  J. Mol. Biol.283, 43-58.

Dai, X. and Rothman-Denes, L. B. (1999). "DNA structure and transcription". Current Opinion in Microbiology 2, 126-130.

Li, B., Mackay, D. R., Dai, Q., Li, T. W. H., Nair, M., Fallahi, M., Schonbaum, C., Fantes, J., Mahowald, A., Waterman, M. L., Fuchs, E., and Dai, XThe LEF1/b-catenin complex activates movo1, a mouse homolog of Drosophila ovo gene required for epidermal appendage differentiation.  (2002).  Proc. Natl. Acad. Sci. USA 99, 6064-6069.

Li, B., Dai, Q., Li, L., Nair, M., Mackay, D. R., and Dai, Xovol2, a mammalian homolog of Drosophila ovo: gene structure, chromosomal mapping, and aberrant expression in blind-sterile mice.  (2002).  Genomics 80, 319-325.