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| Image #3 |
These are samples of results in our chronic stroke studies being directed by postdoc Dr. Magda Guerra-Crespo, using the MCAO (middle cerebral artery occlusion) model of stroke in rodents. In A we can see the lighter areas of infarct and damage, and in J we can see confocal microscopy evidence of colocalization of BrdU (new neurons being generated from adult stem cells) and markers for migrating and differentiating neural cells following administration of TGFa in these rats. The ability of TGFa to induce massive and directed proliferation of adult stem cells in the injured nervous system is also seen in fig a-b-c, where hundreds of thousands of new neural cells (white arrows) have been generated and are seen to migrate toward the injured area where TGFa is also present. This work (Fallon et al 2000) was presented by NIH to Congress in 2001 as evidence that manipulation of adult stem cells in vivo for CNS disorders have therapeutic potential. |
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